Opportunity Information: Apply for PA 17 104
The National Institutes of Health (NIH) funding opportunity titled "Strengthening the HIV Pre-Exposure Prophylaxis (PrEP) Care Continuum through Behavioral, Social, and Implementation Science (R01)" (Funding Opportunity Number: PA 17 104) is a discretionary grant program that supports health-related research aimed at improving how PrEP is delivered, used, and sustained in real-world settings. It focuses on the PrEP care continuum, meaning the full pathway from identifying people who could benefit from PrEP, to linking them to services, initiating PrEP, supporting adherence and persistence, providing ongoing monitoring and follow-up, and ultimately achieving better HIV prevention outcomes. The FOA is positioned within CFDA 93.242 and uses the NIH R01 mechanism, which generally indicates support for substantial, hypothesis-driven research projects with strong scientific rationale and clearly defined aims.
The opportunity specifically calls for behavioral, social, and implementation science research in three major areas. First, it funds studies that identify where the PrEP continuum breaks down and why, including the individual, interpersonal, community, clinical, structural, and policy factors that contribute to these gaps. This can include barriers such as stigma, mistrust, low risk perception, mental health or substance use challenges, transportation and clinic access issues, insurance and cost barriers, provider knowledge and bias, and system-level problems like fragmented referral processes or limited PrEP capacity in certain care settings. The emphasis is not only on describing gaps but also on identifying determinants, meaning the underlying drivers that can be targeted with interventions.
Second, the FOA supports the development and testing of interventions designed to strengthen PrEP delivery and outcomes. This can involve interventions at multiple levels, including patient-facing strategies (for example, tailored navigation, adherence support, digital reminders, peer support, or stigma-reduction approaches), provider-focused strategies (such as training, decision support tools, or workflow redesign), and clinic or community-level implementation approaches (including task shifting, telehealth models, pharmacy-based PrEP, integration into primary care, STI clinics, or community-based organizations, and improved referral and retention systems). Because the FOA highlights implementation science, it encourages applicants to think beyond efficacy and address practical questions of how to adopt, implement, scale, and sustain PrEP programs in diverse settings, including how to measure reach, fidelity, cost, feasibility, acceptability, and long-term maintenance.
Third, a central goal of the announcement is to reduce disparities in PrEP uptake and use, with explicit attention to racial and ethnic inequities and age-related gaps. In practice, this means NIH is looking for projects that do not treat disparities as an afterthought, but instead make equity a core outcome. The FOA is oriented toward improving access and continuity of PrEP among populations that have historically had lower PrEP uptake despite high HIV risk, including many Black and Hispanic/Latino communities and younger people who may face unique barriers related to confidentiality, healthcare access, stigma, and engagement with prevention services. Competitive projects under this announcement would typically be expected to define the disparity being addressed, explain the mechanisms producing it, and test interventions that are culturally responsive and structurally informed.
Eligibility for this opportunity is broad, reflecting an intent to bring in applicants from many sectors involved in HIV prevention. Eligible applicants include state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities, as well as public and state-controlled institutions of higher education and private institutions of higher education. The FOA also allows applications from federally recognized tribal governments and tribal organizations (including those other than federally recognized tribal governments), nonprofits with or without 501(c)(3) status, for-profit organizations other than small businesses, small businesses, and other entities. In addition, the FOA explicitly notes other eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This wide eligibility is consistent with the FOA's emphasis on implementation and community-relevant solutions, since many of the most impactful PrEP delivery innovations occur through partnerships among academic researchers, public health agencies, and community providers.
Administratively, this is an NIH grant opportunity with a creation date of 2017-01-09 and an original closing date listed as 2018-01-24 in the source data provided. The award ceiling and expected number of awards are not specified in the provided fields, which typically means applicants would need to consult the full NIH FOA text and related NIH Institute/Center guidance to understand budget expectations, project period norms, and any institute-specific priorities. Overall, the purpose of the FOA is to generate actionable evidence about where and why PrEP delivery fails across the continuum and to rigorously test interventions that make PrEP easier to access, start, and continue, particularly for populations experiencing persistent disparities in HIV prevention benefits.Apply for PA 17 104
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Strengthening the HIV Pre-Exposure Prophylaxis (PrEP) Care Continuum through Behavioral, Social, and Implementation Science (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
- This funding opportunity was created on 2017-01-09.
- Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Strengthening the HIV Pre-Exposure Prophylaxis (PrEP) Care Continuum through Behavioral, Social, and Implementation Science (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA 17 104.
What type of grant program is this?
This is a discretionary grant program offered by the National Institutes of Health (NIH).
What research mechanism does this opportunity use?
It uses the NIH R01 mechanism, which generally supports substantial, hypothesis-driven research projects with strong scientific rationale and clearly defined aims.
What is the CFDA listing for this opportunity?
This funding opportunity is positioned within CFDA 93.242.
What is the overall purpose of this FOA?
The purpose is to strengthen the HIV PrEP care continuum by generating actionable evidence about where and why PrEP delivery fails and by rigorously testing interventions that improve PrEP access, initiation, adherence, persistence, monitoring, and prevention outcomes in real-world settings.
What does "PrEP care continuum" mean in this announcement?
It refers to the full pathway of PrEP delivery and use, including identifying people who could benefit from PrEP, linking them to services, initiating PrEP, supporting adherence and persistence, providing ongoing monitoring and follow-up, and ultimately achieving better HIV prevention outcomes.
What scientific areas does this FOA emphasize?
The FOA specifically calls for behavioral science, social science, and implementation science research focused on improving the PrEP care continuum.
What are the major research areas supported by this FOA?
The FOA highlights three major areas: (1) identifying where the PrEP continuum breaks down and why, (2) developing and testing interventions to strengthen PrEP delivery and outcomes, and (3) reducing disparities in PrEP uptake and use, including racial/ethnic inequities and age-related gaps.
What does the FOA mean by identifying "gaps" or "breakdowns" in the PrEP continuum?
It means pinpointing where people fall off the pathway (for example, not getting linked to services, not initiating PrEP, not staying adherent or persistent, or not receiving ongoing monitoring) and understanding why those drop-offs occur.
What kinds of factors can studies examine to explain why the continuum breaks down?
The FOA notes factors at multiple levels, including individual, interpersonal, community, clinical, structural, and policy factors.
What example barriers are specifically mentioned in the opportunity description?
Examples include stigma, mistrust, low risk perception, mental health or substance use challenges, transportation and clinic access issues, insurance and cost barriers, provider knowledge and bias, and system-level problems such as fragmented referral processes or limited PrEP capacity in certain care settings.
Does this FOA prioritize simply describing gaps, or also explaining what drives them?
It emphasizes not only describing gaps, but also identifying determinants (the underlying drivers) that can be targeted with interventions.
What kinds of interventions does the FOA support?
The FOA supports developing and testing interventions designed to strengthen PrEP delivery and outcomes, including interventions at patient, provider, clinic, and community levels.
What are examples of patient-facing interventions mentioned in the description?
Examples include tailored navigation, adherence support, digital reminders, peer support, and stigma-reduction approaches.
What are examples of provider-focused strategies mentioned in the description?
Examples include training, decision support tools, and workflow redesign.
What are examples of clinic or community-level implementation approaches mentioned in the description?
Examples include task shifting, telehealth models, pharmacy-based PrEP, integration into primary care, STI clinics, or community-based organizations, and improved referral and retention systems.
Why does the FOA emphasize implementation science?
Because it encourages applicants to address practical, real-world questions about how to adopt, implement, scale, and sustain PrEP programs in diverse settings, not just whether an intervention works under ideal conditions.
What implementation outcomes or measures are specifically referenced?
The description notes measuring factors such as reach, fidelity, cost, feasibility, acceptability, and long-term maintenance.
Is reducing disparities a central goal of this FOA?
Yes. A central goal is to reduce disparities in PrEP uptake and use, with explicit attention to racial and ethnic inequities and age-related gaps.
Which populations are explicitly highlighted in the description as experiencing disparities?
The description highlights many Black and Hispanic/Latino communities and younger people who may face unique barriers to PrEP uptake and continuity despite high HIV risk.
How does the FOA suggest applicants should treat equity and disparities within proposed projects?
The FOA is oriented toward projects that make equity a core outcome. Competitive projects would typically define the disparity being addressed, explain mechanisms producing it, and test interventions that are culturally responsive and structurally informed.
Who is eligible to apply for this opportunity?
Eligibility is broad and includes various government entities, educational institutions, tribal governments and organizations, nonprofits, for-profit organizations (other than small businesses), small businesses, and other entities, including foreign organizations.
Which government entities are listed as eligible applicants?
Eligible government applicants include state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are colleges and universities eligible?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized tribal governments and tribal organizations (including those other than federally recognized tribal governments) are included as eligible applicants.
Can nonprofits apply, and do they need 501(c)(3) status?
Nonprofits with or without 501(c)(3) status are listed as eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed, and small businesses are also listed as eligible.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly notes faith-based or community-based organizations among eligible applicants.
Are U.S. territories or possessions included as eligible applicants?
Yes. Regional organizations and U.S. territories or possessions are explicitly noted as eligible.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA indicates that non-U.S. entities (foreign organizations) are eligible applicants.
Does the provided information specify an award ceiling?
No. The award ceiling is not specified in the provided information.
Does the provided information specify the expected number of awards?
No. The expected number of awards is not specified in the provided information.
What does it mean that award ceiling and expected number of awards are not specified here?
It typically means applicants would need to consult the full NIH FOA text and related NIH Institute/Center guidance for budget expectations, typical project periods, and any institute-specific priorities.
What are the key administrative dates provided for this opportunity?
The creation date is 2017-01-09, and the original closing date listed in the provided source data is 2018-01-24.
What settings does the FOA encourage applicants to consider for PrEP delivery and implementation?
The description references diverse real-world settings, including primary care, STI clinics, pharmacies (pharmacy-based PrEP), telehealth models, and community-based organizations, as well as systems that improve referral and retention.
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