Opportunity Information: Apply for RFA CA 21 009
This funding opportunity, RFA-CA-21-009, is a National Institutes of Health (NIH) National Cancer Institute (NCI) announcement that supports revision applications to existing NCI-funded U54 Resource-Related Research Projects. In practical terms, it is not aimed at brand-new standalone projects. Instead, it is meant for teams that already hold an active NCI U54 award and want to request additional support to expand the parent project or speed up its progress by adding a specific new technology.
The central requirement is that the revision proposes to incorporate a novel technical approach or instrument that was developed with support from the NCI Innovative Molecular Analysis Technologies (IMAT) program. The intent is to move promising IMAT-enabled tools from early development into broader, real-world research use by embedding them within ongoing U54 resource projects. NCI is using this mechanism to encourage independent validation of these emerging technologies, demonstrate their value in a setting beyond the original developers laboratory, and accelerate their readiness and suitability for the cancer research community that would benefit from them.
Programmatically, this FOA sits within the IMAT effort and emphasizes interdisciplinary collaboration, meaning it encourages cross-cutting teams that can bring together technology developers, cancer biologists, clinical or translational researchers, data and computational experts, and others needed to deploy and evaluate the tool effectively. While the parent award is a U54 resource-related project, the FOA is labeled "Clinical Trial Optional," which means applicants may propose work that does or does not meet the NIH definition of a clinical trial, as appropriate for the technology integration and the goals of the parent study.
The award mechanism is a cooperative agreement (U54), which generally implies substantial NIH involvement compared with a standard grant. Under a cooperative agreement, recipients still lead the project scientifically, but NIH program staff typically have an active partnership role, such as participating in steering or oversight activities, helping coordinate across related efforts, or ensuring the project aligns with program goals around technology validation and dissemination.
Eligibility is broad across U.S.-based organizations and includes state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other categories. The announcement also explicitly calls out several institution types as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
At the same time, there are important restrictions related to foreign participation. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply under this FOA. However, foreign components, as defined in NIH policy, are allowed, meaning a U.S. applicant organization can include certain foreign collaborations or activities as part of the project when they meet NIH criteria and are appropriately justified.
The FOA was created on November 24, 2020, and the original closing date listed is September 29, 2021. The opportunity is categorized as discretionary funding and falls under education and health, with CFDA number 93.394. The award ceiling and the expected number of awards are not specified in the provided source information, which typically means applicants need to consult the full FOA text for budgeting guidance, limits, and program expectations.
Overall, the opportunity is best understood as a targeted accelerator for technology adoption: it leverages ongoing U54 research resources and infrastructure to test, validate, and integrate IMAT-supported tools in ways that directly enhance or extend the parent project, while also generating credible evidence and practical experience that helps the broader cancer research field adopt these innovations more quickly.Apply for RFA CA 21 009
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U54 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394.
- This funding opportunity was created on 2020-11-24.
- Applicants must submit their applications by 2021-09-29. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is RFA-CA-21-009?
RFA-CA-21-009 is a National Institutes of Health (NIH), National Cancer Institute (NCI) funding opportunity announcement that supports revision applications to existing NCI-funded U54 Resource-Related Research Projects.
Is this opportunity meant for brand-new standalone projects?
No. This opportunity is not aimed at brand-new standalone projects. It is specifically intended for teams that already hold an active NCI U54 award and want additional support to expand the parent project or speed progress by adding a specific new technology.
What type of application does this FOA support?
It supports revision applications (i.e., additions or expansions to an existing, active NCI-funded U54 parent award), rather than new independent awards disconnected from an existing U54.
What is the central requirement for the proposed revision?
The revision must propose incorporating a novel technical approach or instrument that was developed with support from the NCI Innovative Molecular Analysis Technologies (IMAT) program.
What is the main goal of incorporating IMAT-supported technology into an existing U54 project?
The intent is to move promising IMAT-enabled tools from early development into broader, real-world research use by embedding them within ongoing U54 resource projects.
Why is NCI using this mechanism?
NCI is using this approach to encourage independent validation of emerging IMAT-enabled technologies, demonstrate their value beyond the original developers laboratory, and accelerate readiness and suitability for the broader cancer research community.
Does the FOA emphasize any particular style of collaboration?
Yes. The FOA emphasizes interdisciplinary collaboration, encouraging teams that can bring together technology developers, cancer biologists, clinical or translational researchers, and data/computational experts, among others needed to deploy and evaluate the tool effectively.
How does this FOA relate to the IMAT program?
Programmatically, the FOA sits within the IMAT effort and is designed to accelerate the adoption, validation, and broader utility of IMAT-supported technologies through integration into active U54 resource projects.
What does "Clinical Trial Optional" mean in this announcement?
"Clinical Trial Optional" means applicants may propose work that does or does not meet the NIH definition of a clinical trial, depending on what is appropriate for the technology integration and the goals of the parent U54 project.
What award mechanism is used for this opportunity?
The award mechanism is a cooperative agreement (U54).
What does a cooperative agreement (U54) imply about NIH involvement?
Under a cooperative agreement, the recipient leads the project scientifically, but NIH program staff typically have a more active partnership role than in a standard grant. This may include participation in steering or oversight activities, coordination across related efforts, and helping ensure alignment with program goals related to validation and dissemination.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations, including state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; and other categories listed in the announcement.
Are specific institution types explicitly called out as eligible?
Yes. The announcement explicitly includes eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Can non-U.S. (foreign) organizations apply as the applicant?
No. Non-domestic (non-U.S.) entities are not eligible to apply under this FOA.
Are non-domestic components of U.S. organizations eligible to apply?
No. Non-domestic components of U.S. organizations are not eligible to apply under this FOA.
Are any kinds of foreign involvement allowed at all?
Yes. Foreign components, as defined in NIH policy, are allowed. This means a U.S. applicant organization may include certain foreign collaborations or activities when they meet NIH criteria and are appropriately justified.
What is the FOA creation date?
The FOA was created on November 24, 2020.
What is the closing date listed in the provided information?
The original closing date listed is September 29, 2021.
What is the CFDA number associated with this opportunity?
The CFDA number provided is 93.394.
How is this funding opportunity categorized?
It is categorized as discretionary funding and falls under education and health.
Is the award ceiling specified in the provided information?
No. The award ceiling is not specified in the provided source information, which typically means applicants would need to consult the full FOA text for budgeting guidance and any limits.
Is the expected number of awards specified?
No. The expected number of awards is not specified in the provided source information.
In practical terms, what is this opportunity best understood as?
It is best understood as a targeted accelerator for technology adoption: it leverages ongoing U54 research resources and infrastructure to test, validate, and integrate IMAT-supported tools in ways that enhance or extend the parent project while producing evidence and practical experience to support broader adoption in cancer research.
What kinds of outcomes is NCI trying to promote through this revision mechanism?
Based on the description provided, NCI is trying to promote independent validation, demonstration of value outside the developers laboratory, and faster readiness and dissemination of IMAT-enabled technologies for the cancer research community.
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|---|
| Revision Applications for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional) Apply for RFA CA 21 008 Funding Number: RFA CA 21 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trial Optional) Apply for RFA CA 21 012 Funding Number: RFA CA 21 012 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional) Apply for RFA CA 21 007 Funding Number: RFA CA 21 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P01 Clinical Trial Optional) Apply for RFA CA 21 011 Funding Number: RFA CA 21 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U2C Clinical Trial Optional) Apply for RFA CA 21 010 Funding Number: RFA CA 21 010 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Small Business Transition Grant For Early Career Scientists (R42 Clinical Trial Not Allowed) Apply for RFA CA 21 001 Funding Number: RFA CA 21 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Cellular Cancer Biology Imaging Research (CCBIR) Program (U54, Clinical Trial Not Allowed) Apply for RFA CA 21 002 Funding Number: RFA CA 21 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,250,000 |
| Digital Technologies to Address the Social Determinants of Health in Context of Substance Use Disorders (SUD) (R41/R42 Clinical Trial Optional) Apply for RFA DA 21 031 Funding Number: RFA DA 21 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Digital Technologies to Address the Social Determinants of Health in Context of Substance Use Disorders (SUD) (R43/R44 Clinical Trial Optional) Apply for RFA DA 21 032 Funding Number: RFA DA 21 032 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Novel Approaches to Decrease Stigma of Substance Use Disorders in order to Facilitate Prevention, Treatment, and Support During Recovery (R43/R44 - Clinical Trials Optional) Apply for RFA DA 21 016 Funding Number: RFA DA 21 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $256,580 |
| Music and Health: Understanding And Developing Music Medicine (R01 Clinical Trial Optional) Apply for PAR 21 100 Funding Number: PAR 21 100 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R21 - Clinical Trials Not Allowed) Apply for RFA DA 21 041 Funding Number: RFA DA 21 041 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R01 - Clinical Trials Not Allowed) Apply for RFA DA 21 040 Funding Number: RFA DA 21 040 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| International Research Scientist Development Award (IRSDA) (K01) Independent Clinical Trial Not Allowed Apply for PAR 21 104 Funding Number: PAR 21 104 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| International Research Scientist Development Award (IRSDA) (K01 Independent Clinical Trial Required) Apply for PAR 21 105 Funding Number: PAR 21 105 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Optimizing Multi-Component Service Delivery Interventions for People with Opioid Use Disorder, Co-Occurring Conditions, and/or Suicide Risk (R01 Clinical Trials Optional) Apply for RFA MH 21 145 Funding Number: RFA MH 21 145 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,000,000 |
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