Opportunity Information: Apply for PA 20 192
The NIH Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required) is a discretionary NIH grant opportunity (Funding Opportunity Number PA-20-192) designed to strengthen the nation’s clinical research workforce by supporting established, mid-career clinician-scientists. The core goal is to buy protected time for eligible health-professional doctorates so they can (1) devote a significant portion of their effort to patient-oriented research (POR) and (2) serve as active research mentors, particularly for clinical residents, clinical fellows, and/or junior clinical faculty. In practice, this mechanism is meant to help midcareer investigators maintain and expand a sustained program of human-subjects-focused research while also building a pipeline of newer clinician-investigators through structured mentorship and training in real clinical research settings.
A defining feature of this specific K24 parent announcement is the emphasis on independent basic experimental studies with humans, meaning the supported research must be patient-oriented and involve direct interactions with human participants or human-origin data/specimens in a way that fits NIH’s expectations for human-subjects research. The award is not simply a career development supplement; it is framed as a way to protect time for an investigator who already demonstrates research independence and productivity, so that their clinical and administrative responsibilities do not crowd out continued patient-oriented investigation and high-quality mentoring. The mentoring component is central rather than optional: applicants are expected to function as experienced mentors who can guide multiple trainees or junior faculty, helping them develop rigorous clinical research skills, responsible conduct, and career momentum toward independent funding.
Eligibility is broad at the organizational level, reflecting NIH’s intent to make the mechanism accessible across many sectors involved in health research and clinical training. Eligible applicant organizations include state, county, and city/township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); and Native American tribal organizations (other than federally recognized tribal governments). Nonprofit organizations are eligible whether or not they hold 501(c)(3) status, and both for-profit organizations (other than small businesses) and small businesses are also listed as eligible. The announcement also explicitly calls out additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, Indian/Native American Tribal Governments (other than federally recognized), and U.S. territories or possessions. At the same time, the opportunity makes clear limits around foreign involvement: non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as the applicant organization. However, foreign components are allowed when they meet NIH’s definition under the NIH Grants Policy Statement, which is a common NIH approach that permits certain international collaborations while keeping the applicant institution domestic.
From an administrative standpoint, the opportunity is run by the National Institutes of Health and uses the grant funding instrument. It is categorized under Education, Environment, and Health funding activity areas and is associated with multiple CFDA numbers (93.113, 93.173, 93.213, 93.242, 93.273, 93.279, 93.361, 93.866), reflecting that multiple NIH Institutes and Centers may participate or align the mechanism with different program authorities. The opportunity record shows an original closing date of 2024-05-07 and a creation date of 2020-05-06. Specific fields such as an award ceiling and expected number of awards are not provided in the supplied source data, which typically means applicants need to consult the full NIH funding announcement and the related NIH Institute/Center participation details to understand budget parameters, award duration, and the likely scale of awards.
Overall, this K24 mechanism is best understood as a midcareer stabilizer and multiplier: it protects the awardee’s time to conduct hands-on human research while formally recognizing and resourcing their role as a mentor who can develop the next generation of patient-oriented investigators. The “Independent Basic Experimental Studies with Humans Required” framing signals that NIH expects the supported work to be firmly rooted in studies involving human participants, and that the awardee’s environment should support both the research program and the mentoring plan in a way that leads to measurable trainee development and sustained patient-oriented research productivity.Apply for PA 20 192
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.173, 93.213, 93.242, 93.273, 93.279, 93.361, 93.866.
- This funding opportunity was created on 2020-05-06.
- Applicants must submit their applications by 2024-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required) (PA-20-192)
What is this funding opportunity?
This is the NIH Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required), Funding Opportunity Number PA-20-192. It is a discretionary NIH grant opportunity intended to strengthen the U.S. clinical research workforce by supporting established, mid-career clinician-scientists.
What is the main purpose of the K24 mechanism in this announcement?
The core purpose is to buy protected time for eligible mid-career health-professional doctorate holders so they can (1) devote a significant portion of their effort to patient-oriented research (POR) and (2) serve as active research mentors, especially for clinical residents, clinical fellows, and/or junior clinical faculty.
What does "protected time" mean in the context of this opportunity?
In this announcement, protected time refers to supporting an established investigator so their clinical and administrative responsibilities do not crowd out continued patient-oriented research and structured mentoring activities.
Who is this award designed to support?
It is designed for established, mid-career clinician-scientists who already demonstrate research independence and productivity and who are positioned to sustain and expand a human-subjects-focused research program while mentoring multiple developing clinician-investigators.
Is this award mainly about research, mentoring, or both?
Both. The research component focuses on maintaining and expanding a sustained program of patient-oriented research involving humans, and the mentoring component is central rather than optional. Applicants are expected to function as experienced mentors guiding residents, fellows, and/or junior faculty in real clinical research settings.
Is the mentoring component optional?
No. The information provided describes mentoring as a central expectation of the mechanism. Applicants are expected to serve as active research mentors and to provide structured mentorship and training tied to patient-oriented research.
What kinds of mentees are emphasized in this opportunity?
The opportunity particularly emphasizes mentoring clinical residents, clinical fellows, and/or junior clinical faculty to help build a pipeline of newer clinician-investigators.
What does "patient-oriented research (POR)" mean here?
Based on the description provided, POR is human-subjects-focused research that involves direct interaction with human participants or work with human-origin data/specimens in a way that fits NIH expectations for human-subjects research.
What is the defining feature of this specific K24 parent announcement?
A defining feature is the emphasis on "independent basic experimental studies with humans." This signals that the supported work must be patient-oriented and involve humans (through direct interactions with participants or through human-origin data/specimens) consistent with NIH expectations for human-subjects research.
Does the supported research need to involve human participants?
Yes, the description emphasizes that supported research must be patient-oriented and involve direct interactions with human participants or human-origin data/specimens in a manner consistent with NIH human-subjects expectations.
Is this award described as a supplement to career development?
No. The information provided explicitly distinguishes this from being "simply a career development supplement." It is framed as a mechanism to protect time for investigators who already have independence and productivity, enabling them to continue patient-oriented investigation and deliver high-quality mentoring.
What is NIH trying to accomplish with this award at a workforce level?
The opportunity is intended to strengthen the nation’s clinical research workforce by stabilizing midcareer patient-oriented investigators and multiplying their impact through structured mentoring that develops the next generation of clinician-investigators.
Which agency runs this opportunity and what is the funding instrument?
The opportunity is run by the National Institutes of Health (NIH) and uses the grant funding instrument.
What funding activity areas are associated with this opportunity?
The opportunity is categorized under Education, Environment, and Health funding activity areas.
Which organizations are eligible to apply?
The eligible applicant organizations listed include: state, county, and city/township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); and Native American tribal organizations (other than federally recognized tribal governments).
Are nonprofit organizations eligible, including those without 501(c)(3) status?
Yes. Nonprofit organizations are eligible whether or not they have 501(c)(3) status, based on the eligibility list provided.
Are for-profit organizations eligible?
Yes. Both for-profit organizations (other than small businesses) and small businesses are listed as eligible applicant organization types.
Are institutions serving specific communities explicitly included as eligible?
Yes. The announcement explicitly calls out additional eligible applicant types including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); and Tribally Controlled Colleges and Universities (TCCUs).
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are explicitly listed among additional eligible applicant types.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included among additional eligible applicant types.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly listed as eligible applicant types.
Are non-U.S. (foreign) organizations eligible to apply as the applicant?
No. The opportunity states that non-domestic (non-U.S.) entities are not eligible to apply as the applicant organization.
Can a U.S. organization apply if it has a non-domestic (foreign) component?
The opportunity indicates that non-domestic components of U.S. organizations are not eligible to apply as the applicant organization. However, it also notes that foreign components are allowed when they meet NIH’s definition under the NIH Grants Policy Statement, which is NIH’s typical approach to permitting certain international collaborations while keeping the applicant institution domestic.
What are "foreign components" in this context?
The information provided indicates that foreign components can be allowed if they meet NIH’s definition under the NIH Grants Policy Statement. The specific definition is not provided in the source text, so applicants would need to consult NIH policy for the formal meaning.
What are the associated CFDA numbers for this opportunity?
The opportunity is associated with multiple CFDA numbers: 93.113, 93.173, 93.213, 93.242, 93.273, 93.279, 93.361, and 93.866. This reflects that multiple NIH Institutes and Centers may participate or align the mechanism with different program authorities.
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is PA-20-192.
What is the closing date shown in the opportunity record?
The opportunity record shows an original closing date of 2024-05-07.
When was the opportunity record created?
The opportunity record shows a creation date of 2020-05-06.
Does the provided information list an award ceiling?
No. The supplied information notes that an award ceiling is not provided in the source data.
Does the provided information state the expected number of awards?
No. The supplied information notes that the expected number of awards is not provided.
Where should applicants look for budget parameters and award scale details not included here?
The provided information indicates that applicants typically need to consult the full NIH funding announcement and related NIH Institute/Center participation details for budget parameters, award duration, and the likely scale of awards.
How is this K24 described in practical terms?
In practice, it is described as a way to help midcareer investigators maintain and expand a sustained program of human-subjects-focused research while building a pipeline of newer clinician-investigators through structured mentorship and training in real clinical research settings.
What outcomes does NIH appear to expect from the mentoring plan?
Based on the description provided, NIH expects mentoring that leads to measurable trainee development and career momentum toward independent funding, along with training in rigorous clinical research skills and responsible conduct.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 20 192) also looked into and applied for these:
| Funding Opportunity |
|---|
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required) Apply for PA 20 193 Funding Number: PA 20 193 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required) Apply for PA 20 196 Funding Number: PA 20 196 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required) Apply for PA 20 194 Funding Number: PA 20 194 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed) Apply for PA 20 195 Funding Number: PA 20 195 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) Apply for PA 20 200 Funding Number: PA 20 200 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 20 247 Funding Number: PA 20 247 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Countermeasures Against Chemical Threats (CounterACT) Exploratory/Developmental Projects (R21 Clinical Trial Not Allowed) Apply for PAR 20 253 Funding Number: PAR 20 253 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21) (Clinical Trial Optional) Apply for PAR 20 255 Funding Number: PAR 20 255 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Ethical, Legal and Social Implications (ELSI) (Research R01 Clinical Trial Optional) Apply for PAR 20 254 Funding Number: PAR 20 254 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03) Clinical Trial Optional) Apply for PAR 20 257 Funding Number: PAR 20 257 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $50,000 |
| Emergency Awards: RADx-rad Wastewater Detection of SARS-COV-2 (COVID-19) (U01 - Clinical Trials Not Allowed) Apply for RFA OD 20 015 Funding Number: RFA OD 20 015 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $2,000,000 |
| Research to Improve Native American Health (R21 Clinical Trials Optional) Apply for PAR 20 214 Funding Number: PAR 20 214 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Intervention Research to Improve Native American Health (R01 Clinical Trial Optional) Apply for PAR 20 238 Funding Number: PAR 20 238 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) Apply for RFA ES 20 014 Funding Number: RFA ES 20 014 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $1,750,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 21 047 Funding Number: PA 21 047 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Addressing Health Disparities among Immigrant Populations through Effective Interventions (R01 Clinical Trial Optional) Apply for PAR 21 081 Funding Number: PAR 21 081 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Addressing the Etiology of Health Disparities and Health Advantages Among Immigrant Populations (R01 Clinical trial not allowed) Apply for PAR 21 080 Funding Number: PAR 21 080 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Countermeasures Against Chemical Threats (CounterACT) Research Centers of Excellence (U54 Clinical Trial Optional) Apply for PAR 20 316 Funding Number: PAR 20 316 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $1,750,000 |
| HEAL Initiative: HEALthy Brain and Child Development Study (U01 - Clinical Trial Not Allowed) Apply for RFA DA 21 021 Funding Number: RFA DA 21 021 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| HEAL Initiative: HEALthy Brain and Child Development Study (Collaborative U01- Clinical Trial Not Allowed) Apply for RFA DA 21 020 Funding Number: RFA DA 21 020 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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