Opportunity Information: Apply for HT942524ATRPCRA
The DoD Arthritis Research Program (ATRP) Clinical Research Award (CRA), FY24 (Funding Opportunity Number HT942524ATRPCRA), is a discretionary grant opportunity run through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), under CFDA 12.420. It is designed to fund human-focused clinical research that evaluates arthritis-related disease factors and interventions in ways that produce practical, clinically useful evidence. The overall aim is to improve arthritis disease management, optimize patient outcomes, and generate results that can shape clinical care decisions and, where relevant, inform policy. While the program is military-connected, it is also clear that the intended benefits should extend beyond the military community to Veterans, families, and the general public.
The scope is broad with respect to arthritis type. Proposals may address any form of arthritis, including osteoarthritis, post-traumatic arthritis, inflammatory arthritis, juvenile arthritis, and rheumatoid arthritis, among others. The program places particular emphasis on studies that incorporate sex as a biological variable and on arthritis types that are understudied, reflecting a push to fill gaps in evidence that may be holding back better diagnosis, treatment, and long-term management. Applicants are also encouraged to increase impact by leveraging large existing datasets or tapping into established studies and consortia, which can strengthen statistical power, speed timelines, and improve generalizability of findings.
A central expectation is that applicants clearly explain how their work will reduce disease burden and translate into real-world improvements in patient care. The announcement highlights several required or heavily weighted features. First is impact: applications need to spell out how the expected outcomes would meaningfully improve arthritis management, patient care, and quality of life, rather than simply adding incremental knowledge. Second is military relevance: applicants must connect the research to the military context, such as effects on Service Member readiness, recruitment and retention, recovery after injury, or broader implications for the Military Health System and TRICARE-supported care. Third is a post-award transition plan: the proposal should describe how findings will be moved into practice after the project ends, for example by informing guidelines, being communicated to stakeholders, or supporting the next stage of clinical development.
The CRA can support either clinical research or, optionally, a clinical trial through a dedicated Clinical Trial Option. If a project includes a clinical trial within the period of performance, or is entirely a clinical trial, applicants may select this option, which is meant to better accommodate trial-related costs. For trial applications, the proposal must describe the standard of care and justify any control groups, which signals that reviewers will closely scrutinize ethical and methodological choices like comparators, placebo use, and clinical relevance. Importantly, the program draws a clear line between clinical research and clinical trials using the federal definition in 45 CFR 46.102. In this context, clinical trials involve prospective assignment of human subjects to interventions to evaluate biomedical or behavioral outcomes (including possible placebo/control). In contrast, clinical research here generally refers to observational or non-interventional work with human subjects, specimens, or data, such as studies of disease mechanisms, diagnostic/biomarker or imaging approaches, health disparities, technology development, epidemiology, behavioral research, and outcomes or health services research that do not test an intervention’s safety or efficacy.
Preclinical and animal work are not allowed under this mechanism. The opportunity explicitly states that the CRA is intended for clinical research or clinical trials only, and directs those seeking preclinical or animal support to a different ATRP mechanism (the Focused Research Award). Alongside this clinical emphasis, the program also stresses rigor and reproducibility expectations consistent with best practices in study design and reporting, including principles like randomization, blinding where appropriate, sample-size estimation, and clear data handling procedures.
Applications must include preliminary and/or published data. This is not optional: the program expects applicants to show that the project is grounded in evidence, backed by a strong scientific rationale, and framed around a clear, testable hypothesis informed by critical analysis of the literature. In other words, this mechanism is not meant for early idea exploration without supporting evidence; it is aimed at projects that are ready to produce actionable clinical insights.
The opportunity also aligns with broader CDMRP priorities around advancing women’s health research. Applicants are encouraged to address conditions that affect women uniquely, disproportionately, or differently than men, and to connect sex-based analyses to meaningful improvements in women’s health outcomes and knowledge. For arthritis specifically, this means proposals that examine sex-related differences in disease course, access to care, treatment response, pain experience, functional outcomes, or other clinically relevant dimensions may be particularly responsive, especially if they can plausibly influence practice.
From a funding standpoint, awards are made as grants under 31 USC 6304. The anticipated total costs for the full project period should not exceed $1.5 million for standard Clinical Research Award proposals, or $3.0 million for proposals submitted under the Clinical Trial Option. The program expects to allocate about $6.0 million total in FY24 funds to support roughly three awards in total: approximately two standard CRA awards and one CRA Clinical Trial Option award, depending on application volume, quality, peer and programmatic review outcomes, and federal fund availability. Awards supported with FY24 funds are expected to be made no later than September 30, 2025, and FY24 funds are anticipated to remain available for use until they expire on September 30, 2030.
Eligibility is listed as unrestricted, which generally means the program is open to a wide range of applicant organizations, as long as they meet the opportunity requirements. The original closing date is October 30, 2024. The strongest applications will be those that (1) directly address at least one of the FY24 CRA focus areas referenced in the announcement, (2) present credible preliminary evidence and a rigorous design, (3) show clear military relevance and patient-care impact, and (4) provide a realistic plan for transitioning results into practice, guidance, or the next development step.Apply for HT942524ATRPCRA
- The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Arthritis Research, Clinical Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2024-08-16.
- Applicants must submit their applications by 2024-10-30. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted.
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FAQs: DoD Arthritis Research Program (ATRP) Clinical Research Award (CRA), FY24
What is this funding opportunity?
The FY24 DoD Arthritis Research Program (ATRP) Clinical Research Award (CRA) is a discretionary grant opportunity (Funding Opportunity Number HT942524ATRPCRA) managed through the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), under CFDA 12.420. It supports human-focused clinical research intended to generate practical, clinically useful evidence to improve arthritis disease management and patient outcomes.
What is the main goal of the CRA?
The CRA aims to improve arthritis disease management, optimize patient outcomes, and produce results that can shape clinical care decisions and, where relevant, inform policy. The program expects projects to translate into real-world improvements rather than only adding incremental knowledge.
Who is the sponsoring/awarding agency?
The opportunity is run through the Department of the Army, with USAMRAA administering the grant program as part of the DoD Arthritis Research Program.
Is this opportunity only for military populations?
No. While military relevance is required and must be clearly explained, the intended benefits are expected to extend beyond the military community to Veterans, families, and the general public.
What types of arthritis are eligible topics?
The scope is broad and may include any form of arthritis. Examples listed include osteoarthritis, post-traumatic arthritis, inflammatory arthritis, juvenile arthritis, and rheumatoid arthritis, among others.
Are there specific topic priorities or emphasis areas?
Yes. The announcement emphasizes (1) incorporating sex as a biological variable and (2) addressing arthritis types that are understudied. It also notes alignment with broader priorities around advancing women’s health research, including studying conditions affecting women uniquely, disproportionately, or differently than men.
What kinds of studies does the CRA support?
The CRA supports human-focused clinical research that evaluates arthritis-related disease factors and interventions in ways that generate clinically useful evidence. It can support clinical research and, optionally, a clinical trial through the dedicated Clinical Trial Option.
What is the difference between clinical research and a clinical trial under this opportunity?
The opportunity draws a clear distinction using the federal definition in 45 CFR 46.102. Clinical trials involve prospective assignment of human subjects to interventions to evaluate biomedical or behavioral outcomes (including placebo/control). In contrast, clinical research in this context generally includes observational or non-interventional studies using human subjects, specimens, or data (for example, disease mechanisms, diagnostics/biomarkers, imaging approaches, health disparities, technology development, epidemiology, behavioral research, outcomes research, or health services research) that do not test an intervention’s safety or efficacy.
Are preclinical or animal studies allowed?
No. Preclinical and animal work are not allowed under this mechanism. The CRA is intended for clinical research or clinical trials only, and the announcement directs applicants seeking preclinical or animal support to a different ATRP mechanism (the Focused Research Award).
What is the Clinical Trial Option?
The Clinical Trial Option is a submission pathway for projects that include a clinical trial within the period of performance, or are entirely a clinical trial. It is intended to better accommodate trial-related costs.
If I apply with a clinical trial, are there special requirements?
Yes. Trial applications must describe the standard of care and justify any control groups. This indicates that ethical and methodological choices (such as comparators, placebo use, and clinical relevance) will be closely scrutinized.
Does the CRA require preliminary or published data?
Yes. Applications must include preliminary and/or published data. The program expects a strong scientific rationale and a clear, testable hypothesis informed by a critical analysis of the literature.
Is this award intended for early-stage ideas without supporting evidence?
No. Based on the stated requirement for preliminary and/or published data and the emphasis on a strong rationale and testable hypothesis, this mechanism is aimed at projects ready to produce actionable clinical insights rather than early idea exploration without supporting evidence.
What does the program mean by “impact”?
Impact is a central, heavily weighted expectation. Applicants are expected to explain how outcomes will meaningfully improve arthritis management, patient care, and quality of life, rather than simply contributing incremental knowledge.
What does “military relevance” mean for this CRA?
Applicants must connect the research to the military context. Examples noted include implications for Service Member readiness, recruitment and retention, recovery after injury, and broader impacts on the Military Health System and TRICARE-supported care.
What is a post-award transition plan, and is it required?
A post-award transition plan is expected. The proposal should describe how findings will be moved into practice after the project ends, such as informing guidelines, communicating results to stakeholders, or supporting the next stage of clinical development.
Does the opportunity encourage use of existing data resources?
Yes. Applicants are encouraged to increase impact by leveraging large existing datasets or tapping into established studies and consortia to strengthen statistical power, speed timelines, and improve generalizability.
What rigor and reproducibility expectations are highlighted?
The opportunity stresses rigor and reproducibility consistent with best practices, including principles such as randomization, blinding where appropriate, sample-size estimation, and clear data handling procedures.
What is the maximum budget for a standard CRA application?
The anticipated total costs for the full project period should not exceed $1.5 million for standard Clinical Research Award proposals.
What is the maximum budget for the Clinical Trial Option?
The anticipated total costs for the full project period should not exceed $3.0 million for proposals submitted under the Clinical Trial Option.
How much total funding is expected to be available, and how many awards are anticipated?
The program expects to allocate about $6.0 million total in FY24 funds to support roughly three awards: approximately two standard CRA awards and one Clinical Trial Option award. Actual numbers may vary based on application volume, quality, peer and programmatic review outcomes, and federal fund availability.
What is the award instrument for this opportunity?
Awards are made as grants under 31 USC 6304.
When are awards expected to be made?
Awards supported with FY24 funds are expected to be made no later than September 30, 2025.
How long will FY24 funds remain available?
FY24 funds are anticipated to remain available for use until they expire on September 30, 2030.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning the program is open to a wide range of applicant organizations as long as they meet the opportunity requirements.
What is the application deadline?
The original closing date is October 30, 2024.
What would make an application especially competitive based on the announcement?
The strongest applications are expected to: (1) directly address at least one FY24 CRA focus area referenced in the announcement, (2) present credible preliminary evidence and a rigorous design, (3) show clear military relevance and patient-care impact, and (4) provide a realistic plan for transitioning results into practice, guidance, or the next development step.
Does the opportunity prioritize women’s health research?
It aligns with broader CDMRP priorities around advancing women’s health research. Applicants are encouraged to address conditions affecting women uniquely, disproportionately, or differently than men, and to connect sex-based analyses to meaningful improvements in women’s health outcomes and knowledge.
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