Substance Use Prevention Effectiveness Research Among Youth and Families in the Child Welfare System (R01 Clinical Trial Required) | RFA DA 24 012

Opportunity Information: Apply for RFA DA 24 012

Substance Use Prevention Effectiveness Research Among Youth and Families in the Child Welfare System (R01 Clinical Trial Required) is a National Institutes of Health (NIH) funding opportunity (RFA-DA-24-012; CFDA 93.279) that supports effectiveness research testing real-world interventions or service approaches intended to prevent opioid misuse and opioid use disorder. The focus is explicitly on people connected to the child welfare system: youth, caregivers, foster parents, and families. The central idea is to build a stronger, practice-ready evidence base for prevention programs that can be delivered within child welfare settings or accessed through child welfare referrals, with the long-term aim of reducing both immediate and intergenerational substance use risk in families.

A key feature of the announcement is its broad definition of child welfare involvement. Projects can target families who are at risk of entering the child welfare system, those currently receiving child welfare services, and those who have already exited the system. This wider lens is meant to reflect how prevention needs often begin before formal system entry and can remain important after a case closes, especially for adolescents transitioning to adulthood and for caregivers navigating instability, trauma, or prior substance exposure in the household.

Because this is an R01 clinical trial required opportunity, applicants are expected to conduct rigorous, outcome-focused effectiveness studies in real-world conditions rather than only tightly controlled efficacy studies. In practice, that usually means testing interventions as they would actually be implemented in community and public service environments, accounting for typical staffing, caseload pressures, service constraints, and the complexities of working with families involved in child welfare. The interventions or services under study should be prevention-oriented and specifically aligned with reducing opioid misuse risk or preventing opioid use disorder among the targeted populations.

Eligible applicants span a wide range of domestic organizations and government entities. Public sector applicants can include state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Higher education institutions are eligible, including public and state-controlled institutions as well as private institutions. Tribal eligibility includes federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized, along with tribally controlled colleges and universities (TCCUs). Nonprofit organizations are eligible whether or not they hold 501(c)(3) status, as are for-profit organizations (other than small businesses) and small businesses. The opportunity also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.

Foreign participation is restricted in the usual NIH way for many opportunities: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are not eligible. However, foreign components are allowed as defined in the NIH Grants Policy Statement, meaning a U.S.-based applicant may include certain well-justified international elements (for example, specific expertise, analytic capacity, or other components) if they meet NIH policy requirements and are appropriate to the project.

The posted administrative details indicate the opportunity is a discretionary grant with an award ceiling listed at $600,000. The original closing date shown is 2023-03-15, and the record creation date is 2022-12-16. Overall, the grant is aimed at generating actionable evidence about what prevention approaches actually work for opioid-related outcomes in child welfare-connected populations, with an emphasis on interventions that can be implemented in, embedded within, or linked through the child welfare system to reduce opioid misuse risk across youth and families.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Substance Use Prevention Effectiveness Research Among Youth and Families in the Child Welfare System (R01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
• This funding opportunity was created on 2022-12-16.
• Applicants must submit their applications by 2023-03-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $600,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DA 24 012

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