Opportunity Information: Apply for RFA HG 21 033
The Genome Research Experiences to Attract Talented Undergraduates into the Genomics Field to Enhance Diversity (GREAT) Program is an NIH research education funding opportunity from the National Human Genome Research Institute (NHGRI) using the R25 mechanism (clinical trials not allowed). Its central purpose is to build a stronger, more diverse genomics pipeline by giving undergraduates, especially students from groups underrepresented in the biomedical workforce, structured exposure to genomics research and career paths. The program is designed to motivate and prepare these students to pursue advanced training and long-term careers across the scientific and biomedical sides of genomics, as well as related ethical, social, and legal areas that intersect with genomics.
The funding supports creative, organized educational activities that go beyond typical classroom instruction, with a primary emphasis on hands-on research experiences, skills-development coursework, and strong mentoring. In practice, this means applicants are expected to create programs that help students develop practical research competencies, strengthen their understanding of genomics concepts and methods, and gain professional development support that makes graduate school or other advanced training more attainable. Mentoring is treated as a core feature rather than an add-on, with the goal of helping students build networks, confidence, and sustained engagement in genomics.
A defining feature of the GREAT Program is its focus on collaborative institutional partnerships that run two-year research education programs for undergraduates enrolled at minority-serving institutions (MSIs) or institutions located in IDeA-eligible states (Institutional Development Award eligible). Each partnership must include an MSI or IDeA-eligible institution plus one or more research-intensive institutions or organizations that have the research infrastructure and training environment associated with graduate-level genomics research. This structure is meant to connect students to robust research settings, resources, and role models while maintaining a strong home-institution base that supports recruitment, retention, and ongoing student development.
Eligibility for applicant organizations is broad and includes many U.S.-based public and private entities that can administer a grant and run an education program. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); for-profit organizations other than small businesses; small businesses; and other categories. The announcement also explicitly highlights MSIs and related institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with certain community-based or faith-based organizations, regional organizations, and U.S. territories or possessions.
At the same time, the opportunity places firm limits on foreign involvement. Non-domestic (non-U.S.) entities are not eligible to apply as applicant institutions. In addition, non-domestic components of U.S. organizations are not eligible, and foreign components (as NIH defines them in the NIH Grants Policy Statement) are not permitted. In other words, the program is intended to be fully U.S.-based in terms of applicant eligibility and project components.
Administratively, this is a discretionary grant opportunity (Funding Opportunity Number RFA-HG-21-033) listed under CFDA 93.172. The original closing date shown is January 12, 2022, and the listed award ceiling is $350,000. Overall, the GREAT Program is aimed at creating durable, mentored, research-centered undergraduate experiences in genomics through partnerships that can offer students both strong institutional support and access to high-quality research environments, with the broader goal of improving diversity and representation across the future genomics workforce.Apply for RFA HG 21 033
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Genome Research Experiences to Attract Talented Undergraduates into the Genomics Field to Enhance Diversity (R25 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on 2021-08-03.
- Applicants must submit their applications by 2022-01-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the GREAT Program?
The Genome Research Experiences to Attract Talented Undergraduates into the Genomics Field to Enhance Diversity (GREAT) Program is a National Institutes of Health (NIH) research education funding opportunity from the National Human Genome Research Institute (NHGRI). It uses the R25 mechanism and is intended to build a stronger, more diverse genomics pipeline by providing structured genomics exposure for undergraduates.
What is the main goal of this funding opportunity?
The central purpose is to motivate and prepare undergraduates, especially students from groups underrepresented in the biomedical workforce, to pursue advanced training and long-term careers in genomics. This includes careers on the scientific and biomedical sides of genomics and related ethical, social, and legal areas that intersect with genomics.
Which NIH institute is sponsoring the GREAT Program?
The program is sponsored by the National Human Genome Research Institute (NHGRI), which is part of NIH.
What grant mechanism does the GREAT Program use?
This opportunity uses the NIH R25 research education mechanism.
Are clinical trials allowed under this opportunity?
No. The GREAT Program is specified as "clinical trials not allowed."
Who is the program intended to serve?
It is designed for undergraduates, with a particular emphasis on students from groups underrepresented in the biomedical workforce. The program is structured to support their research skill development, mentoring, and preparation for advanced training pathways in genomics.
What types of educational activities does the GREAT Program support?
The funding supports creative, organized educational activities that go beyond typical classroom instruction. The primary emphasis is on hands-on research experiences, skills-development coursework, and strong mentoring.
Is hands-on genomics research experience a required emphasis?
Based on the program description, hands-on research experiences are the primary emphasis, alongside skills-development coursework and mentoring.
How important is mentoring in the GREAT Program?
Mentoring is treated as a core feature rather than an add-on. The program aims to help students build networks, confidence, and sustained engagement in genomics, while supporting professional development that makes graduate school or other advanced training more attainable.
What is the expected program structure for GREAT awards?
A defining feature is collaborative institutional partnerships that run two-year research education programs for undergraduates. These programs are intended to provide durable, mentored, research-centered experiences in genomics.
What institutions must be involved in a GREAT Program partnership?
Each partnership must include an institution that is either a minority-serving institution (MSI) or located in an IDeA-eligible state, plus one or more research-intensive institutions or organizations with the research infrastructure and training environment associated with graduate-level genomics research.
What is an MSI in the context of this opportunity?
The announcement highlights minority-serving institutions (MSIs) and related institution types, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
What is the purpose of requiring a research-intensive partner?
The partnership structure is intended to connect students to robust research settings, resources, and role models, while maintaining a strong home-institution base that supports recruitment, retention, and ongoing student development.
Where are students expected to be enrolled?
The described program model focuses on undergraduates enrolled at minority-serving institutions (MSIs) or institutions located in IDeA-eligible states.
What types of organizations are eligible to apply?
Eligibility is broad for U.S.-based entities that can administer a grant and run an education program. Eligible applicants include various levels of government (state, county, city or township, special district), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, tribal organizations (not federally recognized), public housing authorities/Indian housing authorities, nonprofit organizations (501(c)(3) and non-501(c)(3)), for-profit organizations other than small businesses, small businesses, and other categories listed in the announcement.
Are community-based or faith-based organizations mentioned as potential applicants?
Yes. The announcement explicitly highlights certain community-based or faith-based organizations, as well as regional organizations and U.S. territories or possessions, in addition to MSIs and related institution types.
Can a non-U.S. organization apply for this grant?
No. Non-domestic (non-U.S.) entities are not eligible to apply as applicant institutions.
Can a U.S. organization include foreign components or foreign project work?
No. Non-domestic components of U.S. organizations are not eligible, and foreign components (as NIH defines them in the NIH Grants Policy Statement) are not permitted. The program is intended to be fully U.S.-based in terms of applicant eligibility and project components.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is RFA-HG-21-033.
What is the CFDA number associated with this opportunity?
The opportunity is listed under CFDA 93.172.
What type of grant is this?
This is a discretionary grant opportunity.
What is the listed application closing date?
The original closing date shown is January 12, 2022.
What is the award ceiling for this opportunity?
The listed award ceiling is $350,000.
What outcomes is the GREAT Program trying to achieve?
The program aims to improve diversity and representation across the future genomics workforce by creating durable undergraduate experiences that build practical research competencies, strengthen genomics knowledge and methods, and provide mentoring and professional development that supports advanced training and long-term engagement in genomics.
Does the GREAT Program focus only on laboratory genomics careers?
No. The description includes preparation for careers across the scientific and biomedical sides of genomics, as well as related ethical, social, and legal areas that intersect with genomics.
Does the GREAT Program fund standard classroom-only instruction?
The supported activities are described as going beyond typical classroom instruction, with a primary emphasis on hands-on research experiences, skills-development coursework, and strong mentoring.
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