Opportunity Information: Apply for RFA OH 24 002

The Exploratory/Developmental Grants on Lifestyle Medicine Research Related to the World Trade Center Health Program (R21) opportunity (RFA-OH-24-002) is a discretionary federal grant sponsored by the Department of Health and Human Services, Centers for Disease Control and Prevention, through NIOSH. It funds early-stage, exploratory research meant to reduce diagnostic and treatment uncertainty for people covered under Subtitle B of the James Zadroga 9/11 Health and Compensation Act of 2010, as amended. The targeted population for these projects is specifically the 9/11-exposed community served by the WTC Health Program, including World Trade Center responders, screening-eligible WTC survivors, and certified-eligible WTC survivors who are receiving monitoring and/or treatment through the Program.

The scientific focus is lifestyle medicine, described here as an evidence-informed clinical approach aimed at preventing, managing, and in some cases reversing chronic diseases, including many conditions already certified as WTC-related health conditions. The opportunity highlights six core lifestyle medicine pillars that applicants can build interventions around: nutrition and diet, sleep hygiene, stress management and positive psychology, physical activity, social connectedness, and avoidance of harmful substance use. The rationale is that sustainable behavior change across these domains can help slow disease progression, reduce the risk of developing additional chronic diseases, and improve outcomes that matter to members, such as well-being, quality of life, and satisfaction with WTC Health Program services. NIOSH also signals that it wants a balanced portfolio of projects and interventions across these lifestyle factors for FY2024, rather than funding proposals that cluster too heavily in only one area.

Because this is an R21 mechanism, the intent is to support the early, conceptual stages of research rather than fully mature programs of work. Projects should test feasibility and explore new directions that could later grow into larger studies or inform real-world clinical practice within the WTC Health Program. The announcement emphasizes innovation and forward motion: studies should break new ground, extend prior findings in new ways, or develop new techniques, methods, models, or approaches with meaningful clinical impact. A key feature of R21s is that applicants are expected to propose approaches where preliminary data may be limited or not available, which lowers the barrier for well-justified, high-potential ideas that still need initial proof-of-concept testing.

Another notable point is how the program defines impact and generalizability. The primary purpose of WTC Health Program research is to benefit the 9/11-exposed population, and the announcement explicitly states that findings do not need to be generalizable to other populations. That gives applicants room to tailor interventions and outcomes to the unique medical, environmental exposure, and psychosocial context of WTC responders and survivors, including program-specific care pathways and the types of chronic conditions commonly seen or certified within the Program.

Administratively, the opportunity is categorized under health (CFDA 93.262) and is open to a wide range of eligible applicants. That includes federal-recognized tribal governments and tribal organizations, state and local governments, special districts, public housing authorities, independent school districts, public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses. The posting listed an expected eight awards. The original application due date was December 5, 2023, with electronic submissions due by 5:00 pm ET. The posted award ceiling field is shown as 0, which typically indicates that a specific maximum dollar cap was not provided in the summary record and applicants should rely on the full funding announcement for budget limits and project period details.

Finally, NIOSH points applicants toward the WTC Health Program Research webpage as the central hub for planning and alignment. That site includes the program research agenda, a publication library, and tools such as a Funding Dashboard that shows awarded projects and details like funded topics, populations studied, award amounts, publications, and principal investigators. In practice, those resources are meant to help applicants shape proposals that match current program priorities, avoid duplication, and build on what has already been learned in the WTC Health Program research portfolio.

  • The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Exploratory/Developmental Grants on Lifestyle Medicine Research Related to the World Trade Center Health Program (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.262.
  • This funding opportunity was created on Aug 18, 2023.
  • Applicants must submit their applications by Dec 05, 2023 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 8 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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