DOD Peer Reviewed Cancer, Clinical Trial Award | HT942525PRCRPCTA

Opportunity Information: Apply for HT942525PRCRPCTA

The FY25 DOD Peer Reviewed Cancer Research Program (PRCRP) Clinical Trial Award (CTA) is a Department of Defense grant opportunity aimed at quickly launching clinical trials that could meaningfully improve how cancer is treated or managed, as long as the proposed trial clearly fits within at least one of the FY25 PRCRP topic areas. The program is oriented toward real-world clinical impact rather than exploratory lab work, and it supports trials that test a broad range of interventions, including new or improved products, drugs or biologics, medical devices, clinical guidance, and other emerging approaches or technologies intended to affect patient care.

A defining requirement of this award is that the application must include a clinical trial. The mechanism is intentionally flexible in terms of trial maturity, allowing studies from very early human testing through more advanced efficacy-focused work. Supported trials can range from small proof-of-concept efforts such as pilot studies, first-in-human testing, or phase 0 trials (often designed to evaluate early signals, feasibility, dosing behavior, or to inform later-stage trial design) up to large-scale clinical trials through phase III that are designed to test efficacy in relevant patient populations.

There are important regulatory readiness expectations tied to this funding. If the proposed clinical trial requires an Investigational New Drug (IND) application or an Investigational Device Exemption (IDE), the applicant must already have an active IND or IDE and must provide documentation showing a determination of "safe to proceed" by the application submission deadline. This requirement also applies to clinical trials that may request an exception from informed consent under 21 CFR 50.24, meaning the program expects regulatory approvals and safety clearances to be in place before the award is even considered, reinforcing the goal of rapid trial initiation rather than funding pre-startup regulatory work.

The award specifically does not allow animal studies. Any necessary preclinical research must be completed before the project begins; the funded period is meant to focus on human clinical testing and the activities required to execute and manage the clinical trial. Applicants should therefore be prepared to demonstrate that the intervention is ready for clinical evaluation, that the trial can begin promptly, and that the team has the operational and compliance infrastructure to run the study successfully.

From an administrative standpoint, the opportunity is offered as a discretionary grant under the Department of the Army, U.S. Army Medical Research Acquisition Activity (USAMRAA), and is listed under CFDA number 12.420. Eligibility is described as unrestricted, indicating that a wide range of applicant types may be able to apply. The funding opportunity number is HT942525PRCRPCTA. The original application closing date is September 25, 2025, and the program anticipates making about 8 awards. A notable FY25 change is that funding limits are now expressed as total costs, meaning the cap includes both direct and indirect costs rather than treating them separately, which affects how applicants should build and justify their budgets.

• The Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD Peer Reviewed Cancer, Clinical Trial Award" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
• This funding opportunity was created on 2025-05-22.
• Applicants must submit their applications by 2025-09-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• The number of recipients for this funding is limited to 8 candidate(s).
• Eligible applicants include: Unrestricted.

Apply for HT942525PRCRPCTA

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